The Reb1-homolog Ydr026c/Nsi1 is required for efficient RNA polymerase I termination in yeast
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چکیده
Please find attached the comments from three scientists that assessed both scientific and technical merits of this interesting contribution. As you will recognize from the enclosed comments, ref#1 advices to broaden the scope of the study addressing further Trf1's recruitment/possible Reb1 competition by further experimentation. Together with necessary clarifications in response to the rather explicit comments of our referees, we would be delighted to receive a revised version for final assessment. This might also present an opportunity to integrate the accepted study on Ydr026c you mentioned in recent communication into your discussion.
منابع مشابه
The Reb1-homologue Ydr026c/Nsi1 is required for efficient RNA polymerase I termination in yeast.
Several DNA cis-elements and trans-acting factors were described to be involved in transcription termination and to release the elongating RNA polymerases from their templates. Different models for the molecular mechanism of transcription termination have been suggested for eukaryotic RNA polymerase I (Pol I) from results of in vitro and in vivo experiments. To analyse the molecular requirement...
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